Increased RHAMM expression relates to ovarian cancer progression
نویسندگان
چکیده
منابع مشابه
Increased RHAMM expression relates to ovarian cancer progression
BACKGROUND Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM's role in ovarian cancer (OC) has not been elucidated. Therefore, we sought to evaluate the role for RHAMM in epithelial OC. RESULTS Despite little to no expression in normal ovarian surface e...
متن کاملIncreased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression
BACKGROUND Paired-like homeodomain 2 (PITX2) is a bicoid homeodomain transcription factor which plays an essential role in maintaining embryonic left-right asymmetry during vertebrate embryogenesis. However, emerging evidence suggests that the aberrant upregulation of PITX2 may be associated with tumor progression, yet the functional role that PITX2 plays in tumorigenesis remains unknown. PRI...
متن کاملIncreased Tumor Necrosis Factor-alpha Expression as an Inflammatory Response Indicator and a Cancer Risk in Polycystic Ovarian Syndrome
Background: Polycystic Ovarian Syndrome (PCOS) is a pro-inflammatory condition that supports the development of metabolic aberration and ovarian dysfunction. Chronic inflammation and the increased levels of androgens in this group of patients and their impact on the immune system may increase the risk of developing malignancies, including ovarian cancer. Thus, we interacted ovarian tumor cells ...
متن کاملHOXB13 promotes ovarian cancer progression.
Deregulated expression of HOXB13 in a subset of estrogen receptor-positive breast cancer patients treated with tamoxifen monotherapy is associated with an aggressive clinical course and poor outcome. Because the ovary is another hormone-responsive organ, we investigated whether HOXB13 plays a role in ovarian cancer progression. We show that HOXB13 is expressed in multiple human ovarian cancer c...
متن کاملStudy of FGF14 gene expression and cancer progression in colorectal cancer tissue samples
Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2017
ISSN: 1757-2215
DOI: 10.1186/s13048-017-0360-1